Gout is the result of purine metabolic disorder caused by a disease, the clinical characteristics of hyperuricemia. Purine is a protein composed of the major components of the human body, mainly from the food and in vivo synthesis. Finally, the formation of uric acid purine decomposition, most of excretion by the kidneys, a small part of the body with the stool. Many patients with hyperuricemia can last a lifetime no symptoms, said anuria hyperuricemia like, only when in the event of arthritis known as gout.
When too much uric acid generation or reduced renal excretion of uric acid can accumulate in the body, the lower the solubility of uric acid, crystallization capacity, sedimentation in a variety of organizations to form a stone. Fatigue, local injury, alcoholism or eating disorders and other factors, can cause acute attacks of gout. Incidence of symptoms from time to time, such as fever chills, etc. The most common symptoms of acute gouty arthritis, which often takes place in the large toe in the toe joints, the ankle may also occur, such as knee and elbow Department. Arthritis onset and more culminate in a day, joint pain, local swelling, the whole red joints. Generally fall ill each limited to one or two joints, can be a recurring problem, caused by joint deformities. Gout patients with high blood concentrations of uric acid can also be deposited in the kidneys, causing kidney stones and lead to kidney dysfunction. Such as deposition or in the subcutaneous tissue around the joints, gout is the formation of nodules.
Because gout is not common, so easy to be misdiagnosed as acute rheumatoid arthritis, rheumatoid arthritis, cellulitis or acute diseases such as septic arthritis, a delay of treatment time. Medical Practice has proved that the disease is not uncommon for gout, but doctors lack the necessary vigilance of suspicious cases, as long as the determination of some serum and urine urate concentration of uric acid it is not difficult to diagnose.
Acute attack of gouty arthritis, bed rest should be in general ease the joint pain to rest 72 hours before recovery activities. Phenylbutazone, indomethacin for the treatment of acute gouty arthritis are special effects, taking 2-3 days, in general there will be a notable improvement in symptoms. In severe cases of the disease, such as treatment with phenylbutazone invalid, the application of adrenocorticotropic hormone or prednisone, the rapid efficacy of such drugs, but easy to stop after the "rebound" relapse, and susceptible to long-term diabetes, high blood pressure complications and therefore do not have as much as possible.
There is no way to cure gout, the key is to prevent recurrent gouty arthritis attacks. Do not overeating usually avoid high-purine diet into, such as animal organs, bone marrow, seafood, crabs and so on. Eat less beef and mutton, ham, sausage, peanuts and other foods. Water to maintain urine output more than 2000 milliliters per day in order to facilitate the discharge of uric acid in vivo. Blood uric acid, such as high salt content, can serve different allopurinol to prevent uric acid production, or service to promote uric acid excretion of probenecid to reduce the concentration of uric acid in blood in order to prevent gout attacks. It is worth noting that patients with gout is often accompanied by hypertension, high cholesterol, arteriosclerosis, coronary heart disease and diabetes, treatment should be balanced.
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