Clinical manifestations of malignant lymphoma

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At the lesion site and extent of the different clinical manifestations of lymphoma varied. The primary lesion can be found in lymph nodes, can also be found in organs other than lymph nodes, such as the tonsils, nasopharynx, gastrointestinal tract, spleen, bones and skin and other places, especially with multiple extra-nodal disease in non-Ho shower. The spread of disease methods are from the primary site and the adjacent lymph nodes followed by communicators, such as Hodgkin's disease, but also to the distance across the adjacent lymph nodes spreaders commonly found in non-Hodgkin's lymphoma.

Non-Hodgkin's lymphomas can also originate multi-center, so the body early in the disease has spread often. Lymphoma may be only a single group of lymph nodes and not accompanied by systemic symptoms, but also there is no superficial lymph nodes and systemic infiltration, accompanied by appropriate symptoms and signs. Hodgkin's disease often see symptoms of superficial lymph nodes, led, primary tissues and organs outside the lymph nodes were only 9%, instead of the primary Hodgkin's lymphoma in the lymph nodes are more than those who see transformed into leukemia, either.

(A) Symptoms
Systemic symptoms of lymphoma sub-type of disease due to different times and locations vary widely, some patients can no systemic symptoms. Have symptoms of fever, weight loss (more than 10% weight loss), and sweating is more common, followed by a loss of appetite, fatigue, itching and so on. Systemic symptoms and age of onset, tumor extent, and so have the relevant immunity. Elderly patients with poor immune function or multi-focal-onset persons, systemic symptoms significantly. No systemic symptoms, their survival rate more symptoms three times as large.

1, fever
Hot multi-irregular, was sustained high fever may also be intermittent low heat, heat a small number of cycles, which met on 1 / 6 of Hodgkin's patients. Early fever were Hodgkin's disease accounts for about 30% to 50%, but leaching promoted or demoted, non-Hodgkin's tumor is usually in the more extensive lesions when the fever. Thermal tides Dafa, disease-oriented features can be poured Soon.
2, skin itching
This is a Hodgkin's disease than the specific performance. Pruritus occurred in the Department of focal lesions of the regional lymphatic drainage, body itching tends to occur with lesions in the mediastinum or abdominal cases.
3, alcohol, pain
About 17% ~ 20% of Hodgkin's disease, in 20 minutes after drinking, painful lesions occurred there. Its symptoms can be earlier than other symptoms and X-ray findings, with a certain diagnosis. When the lesion after complete remission, alcohol and pain that the lines disappear, relapse Shiyou reproduce. The mechanism of pain alcohol is unknown.
4, small external symptoms of disease
1). Outside the gastrointestinal tract, according to analysis of 1246 cases of lymphoma cases reflect the occurrence of extranodal lymphoid tissue lymphoma, most lesions in the gastrointestinal tract, in non-Hodgkin's lymphoma accounted for 13% ~ 25%, Hodgkin's disease is only 2% . Clinical manifestations have food, meritocratic wish to subside, abdominal pain, diarrhea, abdominal mass, intestinal obstruction and bleeding. Invasion, and a multi-part to the small intestine, where more than half of the ileum, followed by stomach, colon rarely involved. Primary small intestinal tumor was most common non-Hodgkin's lymphoma can be mal-absorption syndrome, or fat diarrhea as the main clinical manifestation, pathological changes will occur in the jejunum. Gastrointestinal tract lesions in general through the mesenteric lymphatic spread from the retroperitoneal lymph nodes from.
2). Hepatobiliary liver parenchyma invasion may be cited directly liver pain. Diffuse infiltration of the liver or swollen lymph nodes to detect common bile duct pressure when the jaundice may occur. Hodgkin's disease involving the liver, about 15% of those who have jaundice.
3). The clinical manifestations of localized bone pain and bone secondary to detect symptoms of nerve compression.
4). Non-specific damage to the skin are common skin pruritus and prurigo. Pruritus in Hodgkin's disease is more prevalent (85%), may be ahead of other skin rashes appear. Khan is also a serious dual closure can be seen.
5). Tonsils and mouth, nose, throat lymphoma mouth, nasopharynx, clinical swallowing difficulties, nasal obstruction, epistaxis.
6). Other lymphoma infiltration of the pancreas can still occur malabsorption syndrome. Shed mediastinal metastasis to the pericardium Pakistan may cause partial tumor. Invasive breast, thyroid, lacrimal gland, bladder, testes and ovary caused by the corresponding symptoms is rare.
(B) signs:
As the lesion and scope of the different signs of lymphoma, the performance varied. The primary lesion is found in lymph nodes can also be found in organs other than lymph nodes, such as the tonsils, nasopharynx, gastrointestinal department, spleen, bones and skin, etc., especially with multiple extra-nodal disease in non-Hodgkin's lymphoma. The spread of disease methods are from the primary site to nearby lymph nodes followed by communicators, such as Hodgkin's disease, but also to the distance across the adjacent lymph nodes spreaders commonly found in non-Hodgkin's lymphoma. Non-Hodgkin's lymphoma, multi-center politicians can originate, so the body early in the disease has spread often. Lymphoma may be only a single group of lymph nodes and not accompanied by systemic symptoms, but also there is no superficial lymph nodes and systemic infiltration, accompanied by appropriate symptoms and signs. Hodgkin's disease often see signs of superficial lymph nodes, led by former hair pouring Deng node tissues and organs other than those only 9% instead of the primary Hodgkin's lymphoma in the lymph nodes are more than those who see, is not transformed into leukemia less.
1, swollen lymph nodes
Disease-oriented features of lymph nodes. Superficial lymph nodes painless, progressive enlargement is often a first manifestation, particularly in the neck lymph nodes as the more common, followed by the axilla, starting at the groin or lower on the pulley. Hodgkin's disease first appeared in opera lymph nodes accounted for 60% to 70%, the left than the right. Supraclavicular lymph nodes have been disseminated lesions prompted, right from the mediastinum or the lungs, usually from the left retroperitoneal. Swollen lymph nodes may engage in activities, Luo bone-like feeling; time course of good shows, promoted or demoted, leaching of various sizes around the knot appeared swollen, and can integrate into the group block. If the lymph nodes increased rapidly, and even violations of the nerves can cause pain. A small number of patients believed to be deep but not superficial lymph nodes. Non-Hodgkin's lymphoma in order to sprinkle curry favor with the onset swelling accounted for 56%, half occur in the neck, but more likely involving the oropharynx ring, mesenteric and groin. Mediastinal lymph nodes common in Hawking's disease, especially among young patients (nodular sclerosis are often bilateral swelling), a diffuse lymph nodes found in cough caused by lymphoma; prognosis are relatively poor. Deep lymph nodes can cause compression symptoms, such as the mediastinal lymph nodes caused by coughing, chest tightness, shortness of breath, pulmonary atelectasis, cervical sympathetic paralysis syndrome, superior vena cava syndrome; hilar lymphadenopathy, jaundice from common bile duct pressure and hepatomegaly; sprinkle curry favor with retroperitoneal swelling in, can cause back pain and lower extremities, perineum, or scrotum edema, oppression ureter, renal pelvis caused by stagnant water. Involving the deep lymph nodes, the clinical manifestations often fever as the main.
2, signs of extranodal disease
1). Hepatic parenchymal invasion can cause liver and spleen enlargement, a biopsy is about 25% to 50% of non-Hodgkin's lymphoma involving the liver, particularly common in follicular or diffuse small-cleaved cell non-Hodgkin's lymphoma. Spleen infiltration mostly by pouring Umayaui abdominal lesions spread through the lymphatic vessels from. Hodgkin's disease of early splenomegaly is not common, but rather increase as their illness progresses, generally about 10%. Hodgkin's disease splenomegaly pathological examination, only 32% of lesions, showing that the degree of splenic involvement is not consistent with clinical findings. Splenomegaly seen in 30% ~ 40% of early adult non-Hodgkin's lymphoma. Department of Hodgkin's disease liver disease spread from the spleen through the portal vein from, so liver lesions, spleen have been victimized, the patient prognosis is poor.
2). The chest in the 100-Hodgkin's lymph node, about 25% in the course of the disease occurred in the chest and liquid, in addition to tumor invasion involving the outer world may be a result of mediastinal lymphatic resistance due to cold.
3). Bone malignant lymphoma bone may have partially by tenderness, pathologic fracture. Hodgkin's disease of bone involving accounted for 10% ~ 35%, non-Hodgkin's lymphoma more to thoracic, lumbar spine most commonly involved, femur, ribs, pelvis and skull second, and more from the ingot at the blood-line broadcast casual or self-induced near the soft-tissue tumor infiltration. X ray showed dentine spine (ivory vertebra) or osteolytic changes. About 4 diffuse large cell or tissue-cell non-Hodgkin's lymphoma, even may be primary in the bone tissue; patients younger. I have long bones, mainly osteolytic changes in the nucleus lesions on the radiation-sensitive clinical have a certain significance.
4). Skin-specific skin lesions more common in adult T-cell leukemia / lymphoma syndrome, or mycosis fungoides, the performance of diversity, including the mass, subcutaneous nodules, infiltrative plaques, ulcers, papules and so on, often first seen in head and neck. At Ye Hao Guan herpes with Hodgkin's disease, accounting for 5% ~ 16%. Ichthyosis, exfoliative erythroderma have dual can be seen. Lymphoma involving the skin are often prompted to disease has entered a late stage and have hematogenous. However, a small number of primary cutaneous Hodgkin's disease and mycosis fungoides, you can long-term survival.
5). Tonsils and mouth, nose, throat lymphoma mouth, nose, throat were, 96% of the original lymphocyte and diffuse histiocytic non-Hodgkin's lymphoma, occurring most parts of the soft palate, tonsils, followed by the nasal cavity and paranasal sinuses, nasopharynx, and tongue less. Clinical visible local tumor and the submandibular lymph nodes.
6). Renal autopsy in 696 cases of malignant lymphoma with renal infiltration accounted for 33.5%, has also been reported as high as 60%; with non-Hodgkin's lymphoma for more than Hodgkin's disease is only 13%. Often the side of lesion, the majority of nodular infiltration. Kidney infiltration by only 23% have clinical manifestations, 10% of kidney swelling, high blood pressure and blood urea nitrogen retention, the other still see the renal pelvis in the nephritis, nephrotic syndrome, renal pelvis and has been frequently reported. Renal biopsy found no tumor infiltration. But the display showing membranous nephropathy, is an immune complex deposition in the renal lesions caused. Lymphoma Remission with nephrotic syndrome also will be improved.
7). The nervous system caused by the central nervous system symptoms involving 100 appointments at 10% of non-Hodgkin's lymphoma, particularly diffuse nature of the original cells, small non-cleaved and large cell lymphoma. Retroperitoneal lymphoma can be foraminal perineural lymphatic violation of the vertebral column and spinal cord, resulting in spinal cord compression syndrome, causing paraplegia and urinary retention, etc., Hodgkin's disease incidence is about 3% ~ 7.5%. Can also be a result of paraplegia caused by epidural tumor invasion. Violation of cauda equina tumor, it can cause lower extremity pump

Pain, numbness Sacrococcygeal pain and walking difficulties and so on. Infiltration is a progressive brain diffuse large-cell non-Hodgkin's lymphoma, a common complication, most violations of meninges, brain parenchyma involving those rare. Patchy tumor infiltration, can cause cranial nerve

Disease, ophthalmoplegia, and diplopia. Non-Hodgkin's lymphoma involving the spinal cord rare.
8). Other lymphoma infiltration of the pancreas can still occur malabsorption syndrome. Mediastinal lymphoma transferred to the pericardium, may cause local tumor. Invasive breast, thyroid gland, oil gland, bladder, testes and ovary symptoms are caused by the corresponding Han See.





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