The cause of vulvar cancer

First, leukoplakia. Pathogenesis of vulvar disease with the close. According to statistics prior to the onset with leukoplakia were about 30 ~ 50%. Because of leukoplakia of the knowledge and diagnostic criteria are not uniform instead of a comparative analysis, so now there are different views on this issue. More consistent view is that can not be genital skin or mucous membranes pale referred to as "white spot", and called the white lesions, and then based on clinical and microscopic features of the name. "Leukoplakia" only applies to genital epithelium with atypical hyperplasia (N0vak1974), there should be varying degrees of histological features of cell shape (Lever, 1975). ZHANG Bao and that should be in accordance with leukoplakia lesions are invariably classified atypical hyperplasia and cancer (1977). As early as 1940 Taussing that 50% of the cancerous leukoplakia can occur, 70% of squamous cell carcinoma patients complicated with white spots. Framklin1972-year retrospective study that 50% of the untreated destined to develop cancer of the white spots. Genital pathology of proliferative lesions without treatment, 10 to 20% of cancer, there is atypical hyperplasia were more likely cancer (Gardner, 1969). Vulvar dystrophy (also known as vulvar white lesion) were cancer rate is less than 5% (Jeffcoate, 1966), Cao Quan-sun and internal reports (1980) of 2%. Thus, the key is whether the vulvar squamous cell hyperplasia, but not by virtue genital skin or mucous membrane white to predict the likelihood of cancer.

Second, syphilitic closely related to chronic ulcers and vulva. Generally reported that there is a history of syphilis accounted for 13 ~ 50%. Determination of Union Hospital, 28 cases of vulvar cancer serum Cornwall's positive reaction in 8 cases (for the liberation of the early cases), accounting for 28.5%. And that the vulvar cancer cases of syphilis sero-positive rate compared with patients 5 ~ 6 times higher. JapazeH et al (1977) Statistics 192 cases of vulvar cancer-positive serum syphilis accounted for 20%. Lnmin (1949) Statistics 60% of vulvar cancer lymph node granulomas. Shandong "Practical Gynecology," a book collection of national five units of 162 cases of vulvar cancer (1956 ~ 1964), sexual history accounted for 41%. All these show that vulvar cancer and sexually transmitted diseases may be relevant.

Third, chronic inflammation of the vulva may be predisposing factors to stimulate the other from the epidemiological JapazeH found that body fat accounted for 64% of patients with diabetes accounted for 24%. Frequently accompanied by obesity and diabetes in patients with acute and chronic inflammation of the vulva to promote precancerous lesions.

4, the virus causes. In Bowen's disease cause of the disease, from discovery of the virus particle electron microscopy (Bhawen, 1980). Verrucose cases is probably caused by a virus (Japaze H, 1977). Another example is 15% (Framklin1972) ~ 34% (Merril, 1970) accompanied by vulvar cancer (in situ or invasive carcinoma), while herpes simplex virus type Ⅱ of the pathogenesis of cervical cancer. Caused by a virus chronic lymphocytic granuloma is one of the most common of the granuloma.

Recently that the human papilloma virus (HPV) can cause flat condyloma, it may be cervical cancer or other cancers caused by one of the. Because in cervical intra-epithelial carcinoma-like change, that is, cervical precancerous lesions and cervical squamous cell carcinoma in situ in patients with this virus and warts exist. Through hybridization, found that HPV, HPV can be a special peroxidase staining was found in the cell. Herpes simplex virus type Ⅱ and the relationship between HPV, the former on the latter played a catalytic role. http://www.tcmwell.com






tags: Cancer Vulvar